The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis

ABSTRACT PURPOSE: To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment. METHODS: Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grades of phlebitis through visual observation and histopathological examination were observed. The second series had also 24 rabbits. Interventions were performed 12 hours after vincristine infusion. These rabbits were randomly divided into four groups, according to treatment: Hirudoid (bid), Xianchen (daily), Xianchen (tid), Xianchen (five times a day). Four days after intervention, the venous injury through visual observation and histopathological examination were evaluated. RESULTS: Series 1: Phlebitis appeared 12 hours after infusion of vincristine through visual observation. There was a significant difference (p<0.05) between 6 hours and 24 hours, 6 hours and 18 hours through visual observation. However, the inflammation happened 6 hours after infusion, the loss of venous endothelial cells demonstrated differences among four groups through histopathological evaluation (p<0.05). There were significant differences (p<0.05) after 4 days among the intervention groups through visual observation, the effects of Xianchen group (five times a day) were better than Xianchen group (tid) (p<0.01). The treatment of edema demonstrated differences among groups through histopathological evaluation (p<0.05), Xianchen (five times a day) better relieved the degree of edema (p<0.05). CONCLUSIONS: The study showed that inflammatory reaction of phlebitis appeared early. Xianchen can treat vincristine induced phlebitis, as well as Hirudoid. It is particularly effective in the treatment of edema, and there is a remarkable dose-response relationship.

Síndrome da Luva Púrpura: principais intervenções preventivas e terapêuticas de enfermagem / Purple Glove Syndrome: main preventive and therapeutic nursing interventions

A Síndrome da Luva Púrpura, complicação relacionada à administração de fenitoína por cateteres intravenosos periféricos, caracteriza-se pelo surgimento de lesões teciduais no local de administração do fármaco, que variam de flebite à necrose local, sendo possível se identificar, nos casos mais severos, evolução para a síndrome compartimental e suas graves conseqüências. Este estudo teve por finalidade descrever a Síndrome da Luva Púrpura e os principais cuidados preventivos e terapêuticos de enfermagem. Identificaram-se 15 publicações sobre a temática, das quais incluíram-se dez artigos. Desta forma foi possível verificar as características da síndrome, bem como propor as principais intervenções de enfermagem, tanto na prevenção quanto no cuidado.

The Purple Glove Syndrome, complication related to the administration of phenytoin through peripheral intravenous catheters, is characterized for the development of injuries in the site of catheter placement. Injuries range from phlebitis to local necrosis, being possible to identify in most severe cases, the development of the compartmental syndrome and its severe consequences.To describe the Purple Glove Syndrome and the main preventive and therapeutic nursing care. A literature search on the topic was conducted. This search provided enough information to characterize the purple glove syndrome as well as to identify main nursing interventions for the prevention and management of the syndrome.

El Síndrome del guante púrpura, complicación relacionada a la administración de fenitoína por catéteres intravenosos periféricos, se caracteriza por el surgimiento de lesiones teciduales en el lugar de la administración del fármaco, que varían de flebitis a la necrosis local, siendo posible identificarse, en los casos más severos, evolución para el síndrome compartimental y sus graves consecuencias. Este estudio tiene por finalidad describir el Síndrome del guante Púrpura y los principales cuidados preventivos y terapéuticos de enfermería. Se identificaron 15 publicaciones sobre la temática, de las cuales se incluyeron diez artículos. Fue posible verificar las características del síndrome, así como proponer las principales intervenciones de enfermería, tanto en la prevención como en el cuidado.

Flebotrombosis y antiparasitarios: coincidencia poco usual / Phlebothrombosis and antiparasitics: unusual coincidence

Se presentan 12 casos en los cuales coinciden procesos de trombosis o flebitis de miembros pélvico con el uso oral de medicación derivada de imidazoles: para tratamiento de patología digestiva, dermatológica o ginecológica. Ocho casos presentaban factores de riesgo como: tromboflebitis previas, uso de estrógenos o derivados, infecciones severas, traumatismos. Llaman la atención tres casos de flebotrombosis poplítea derecha en varones sitio sin otro aparente factor de riesgo. Se hace mención de un caso de trombosis u obstrucción arterial distal. Se hace una revisión de las complicaciones habituales reportadas con estos medicamentos y su interacción con los anticoagulantes orales. Sugerimos para ratificar o rectificar tal observación, incluir en el interrogatorio de pacientes con trombosis o flebitis de etiología no identificada, la investigación del uso de imidazoles y derivados